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Xiao-Jian Zhou Selected Research

AT-511

1/2021AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19.
1/2019Safety, pharmacokinetics and antiviral activity of AT-527, a novel purine nucleotide prodrug, in HCV-infected subjects with and without cirrhosis.

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Xiao-Jian Zhou Research Topics

Disease

8Infections
01/2024 - 03/2006
7Neoplasms (Cancer)
02/2012 - 06/2005
5Squamous Cell Carcinoma of Head and Neck
03/2010 - 10/2008
5Chronic Hepatitis B
06/2009 - 09/2004
4COVID-19
05/2024 - 01/2021
3Fibrosis (Cirrhosis)
01/2024 - 01/2019
3Asthma (Bronchial Asthma)
11/2021 - 09/2011
3Liver Diseases (Liver Disease)
01/2013 - 05/2006
3Chronic Hepatitis C
01/2013 - 01/2012
2Squamous Cell Carcinoma (Epidermoid Carcinoma)
02/2010 - 03/2009
2Chronic Kidney Failure (Chronic Renal Failure)
06/2009 - 12/2007
2Carcinogenesis
03/2009 - 05/2008
1Dengue (Dengue Fever)
03/2024
1Atopic Dermatitis (Atopic Eczema)
10/2022
1Eczema
10/2022
1Hepatitis C
05/2014
1Viremia
12/2012
1Virus Diseases (Viral Diseases)
12/2012
1Breast Neoplasms (Breast Cancer)
02/2012
1Neoplasm Metastasis (Metastasis)
03/2010
1Carcinoma (Carcinomatosis)
02/2010
1Tongue Neoplasms (Tongue Neoplasm)
02/2010
1Body Weight (Weight, Body)
06/2009
1Lymphatic Metastasis
12/2008
1Adenoid Cystic Carcinoma (Cylindroma)
07/2007
1Acquired Immunodeficiency Syndrome (AIDS)
06/2005

Drug/Important Bio-Agent (IBA)

14Antiviral Agents (Antivirals)IBA
05/2024 - 09/2004
6TelbivudineFDA Link
06/2009 - 09/2004
4NucleotidesIBA
05/2024 - 12/2012
4Proteins (Proteins, Gene)FDA Link
05/2014 - 07/2007
3NucleosidesIBA
08/2012 - 05/2006
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
02/2012 - 02/2010
2ProTidesIBA
05/2024 - 01/2019
2GuanosineIBA
05/2024 - 01/2021
2Vitamin DFDA LinkGeneric
10/2022 - 09/2013
2montelukast (Singulair)FDA Link
11/2021 - 09/2011
2AT-511IBA
01/2021 - 01/2019
2RNA (Ribonucleic Acid)IBA
05/2014 - 12/2012
2IDX184IBA
01/2013 - 12/2012
2Ribavirin (Virazole)FDA LinkGeneric
01/2013 - 01/2012
2Alanine Transaminase (SGPT)IBA
01/2013 - 12/2012
2NF-kappa B (NF-kB)IBA
03/2010 - 02/2010
2CreatinineIBA
06/2009 - 12/2007
1AT-752IBA
03/2024
1Fluticasone (Cutivate)FDA LinkGeneric
11/2021
1Salmeterol Xinafoate (Serevent)FDA Link
11/2021
1ProdrugsIBA
01/2021
1remdesivirIBA
01/2021
1purineIBA
01/2019
1samatasvirIBA
05/2014
1LipopolysaccharidesIBA
09/2013
1Interleukin-17 (Interleukin 17)IBA
09/2013
1Interleukin-13IBA
09/2013
1Transaminases (Aminotransferases)IBA
12/2012
1IDX 899IBA
08/2012
1Reverse Transcriptase InhibitorsIBA
08/2012
1TNF-Related Apoptosis-Inducing LigandIBA
02/2012
1Small Interfering RNA (siRNA)IBA
02/2012
1CytokinesIBA
02/2012
1Protease Inhibitors (Protease Inhibitor)IBA
01/2012
1InterferonsIBA
01/2012
1Viral RNAIBA
01/2012
1IDX320IBA
01/2012
1Transforming Growth Factor beta (TGF-beta)IBA
09/2011
1Messenger RNA (mRNA)IBA
09/2011
1Leukotriene Antagonists (Leukotriene Receptor Antagonists)IBA
09/2011
1LuciferasesIBA
03/2010
1Peptide Hydrolases (Proteases)FDA Link
02/2010
1shikoninIBA
02/2010
1CaspasesIBA
02/2010
1Biomarkers (Surrogate Marker)IBA
03/2009
1Insulin-Like Growth Factor Binding Protein 3IBA
12/2008
1ImmunosorbentsIBA
10/2008
1alpha-Fetoproteins (alpha-Fetoprotein)IBA
10/2008
1Phosphopyruvate Hydratase (Enolase)IBA
10/2008
1Tumor Biomarkers (Tumor Markers)IBA
10/2008
1Carcinoembryonic AntigenIBA
10/2008
1Tissue Polypeptide AntigenIBA
10/2008
1EnzymesIBA
10/2008
1AntigensIBA
10/2008
1Benzo(a)pyreneIBA
05/2008
1Cadherins (E-Cadherin)IBA
07/2007
1adefovir dipivoxil (Hepsera)FDA Link
07/2006
1Lamivudine (Epivir)FDA Link
07/2006
1Fluorouracil (Carac)FDA LinkGeneric
06/2005
1UridineIBA
06/2005
1pyrimidineIBA
06/2005
1Hepatitis B e AntigensIBA
09/2004

Therapy/Procedure

5Therapeutics
11/2021 - 09/2004
1Duration of Therapy
01/2012
1Renal Dialysis (Hemodialysis)
12/2007
1Oral Administration
03/2006